Metoprolol should be taken orally, on an empty stomach, during or immediately after a meal.
Tablets can be divided in half (but not chewed) and washed down with liquid.
- Arterial hypertension
100-200 mg of metoprolol once in the morning or in two doses: morning and evening. If necessary, the dose can be increased or another antihypertensive agent added. Long-term antihypertensive therapy with 100-200 mg of metoprolol per day can reduce overall mortality, including sudden death, as well as the incidence of cerebral strokes and coronary circulation disorders in patients with arterial hypertension
100-200 mg per day in two divided doses: morning and evening. If necessary, another antianginal agent may be added to the therapy
- Heart rhythm disturbances, including supraventricular tachycardia
100-200 mg per day in two divided doses (morning and evening). If necessary, another antiarrhythmic agent may be added to the therapy
- В комплексной терапии после инфаркта миокарда
The maintenance dose is 200 mg per day in two divided doses (morning and evening). The administration of metoprolol at a dose of 200 mg per day can reduce mortality in patients who have had myocardial infarction, and reduce the risk of developing myocardial infarction (including patients with diabetes mellitus)
- Functional disorders of cardiac activity accompanied by tachycardia
100 mg metoprolol once a day, it is recommended to take a tablet in the morning. If necessary, the dose may be increased
- Prevention of migraine attacks
100-200 mg per day in two divided doses: morning and evening
150-200 mg per day in 3-4 doses
- Use in patients with renal failure
In case of impaired renal function, dose adjustment is not required
- Use in patients with liver failure
Given the low degree of association of metoprolol with plasma proteins, dose adjustment is not required. However, in severely impaired liver function (in patients with severe liver cirrhosis or portocaval anastomosis), a dose reduction of metoprolol may be required
- Use in elderly patients
Elderly patients are recommended to start treatment with 50 mg per day (since a sharp decrease in blood pressure or increasing bradycardia may be more pronounced)
Actions when it is necessary to cancel the drug:
If there is a need to interrupt or stop treatment with metoprolol after prolonged therapy, the dosage of the drug should be gradually reduced by 2 times for at least 2 weeks.
When the “withdrawal” syndrome appears, the dose reduction should be slower. A sharp cessation of the drug can cause myocardial ischemia and can lead to an exacerbation of the course of angina pectoris or myocardial infarction, as well as increase arterial hypertension.