prescribed in a dose of 75-100 mg per day in 2-3 doses. In case of insulin-dependent diabetes mellitus (type 1) with microalbuminuria (release of albumin 30-300 mg per day), the dose is 50 mg 2 times a day. With a total protein clearance of more than 500 mg per day, the drug is effective at a dose of 25 mg (1/2 tablet of 50 mg) 3 times a day. With a moderate degree of impaired renal function (GFR - at least 30 ml/min/1,73 sq.m) can be prescribed in a dose of 75-100 mg per day. With a more pronounced degree of impaired renal function (GFR - less than 30 ml/min/1,73 sq.m), the initial dose should be no more than 12,5 mg per day (for this dosage regimen, captopril should be used in 25 mg tablets with the risk of others manufacturers); in the future, if necessary, the dose is gradually increased at sufficiently long intervals, but a smaller daily dose of the drug is used than in the case of treatment of arterial hypertension. If necessary, “loop” diuretics are additionally prescribed, and not thiazide diuretics.